Results of Epidemiological and Microbiological Monitoring of Healthcare- Associated Infections in the Republic of North Ossetia–Alania

Introduction: The complex of exogenous and endogenous risk factors in multidisciplinary hospitals creates conditions for the development nosocomial infections induced by ESKAPE pathogens. Objective: To establish epidemiological features etiological significance antibiotic resistant strains leading pathogens inducing hospital-acquired to determine their prevalence clinics Republic North Ossetia–Alania. Materials methods: We analyzed incidence results microbiological monitoring antimicrobial drug resistance years 2012–2021. Detection genes encoding production metallo-β-lactamases was performed P. aeruginosa strains, extended-spectrum β-lactamases PFGE profiles E. coli K. pneumoniae strains. Results: In Ossetia–Alania, average long-term rate study period 0.74 per 1,000 inpatients. established that 44.2 % all such cases were diagnosed surgical departments, 32.4 – maternity 6.6 pediatric 16.8 other clinical departments. highest (0.85 patients) departments surgery, most prevalent being injection site infections, lower respiratory tract urinary infections. structure Enterobacteriaceae spp., Staphylococcus spp. rates estimated based on 2.5 times higher than those registered within routine surveillance system. Conclusions: Incidence healthcare-associated Ossetia–Alania are comparable Russian Federation. Patients surgery at Optimization preventive measures requires a risk-based approach takes into account in-depth data common drugs choice local hospitals.